Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926582 | 0.89 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6926572 | 0.87 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6720224 | 0.79 | LMNA (0.70) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL193275 | 0.77 | TSHR (0.68) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL30443852 | 0.77 | TSHR (0.68) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL426359 | 0.74 | USP10 (0.51) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL10231311 | 0.73 | HSP90AA1 (0.62) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL10090763 | 0.73 | SMN1; SMN2 (0.70) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL544644 | 0.72 | TSHR (0.68) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6647253 | 0.71 | MEN1 (0.72) | MEN1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403633-B2 | USEFUL ANTIANGIOGENIC, ANTIARTHRITIC, ANTIINFLAMMATORY, ANTIRESTENOTIC, ANTIINVASIVE, ANTIMETASTIC, ANTIOSTEOPOROTIC, ANTIRETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC TREATMENT AGENTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-06-11 | — | — | US | disclosed |