SCHEMBL7736552

SCHEMBL7736552

[CH2]CC#CC(c1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.44
HTR2A P28223 2/20 0.36
TAAR1 Q96RJ0 2/20 0.36
DPP4 P27487 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HRH1 P35367 2/20 0.33
TSHR P16473 2/20 0.33
MTOR P42345 1/20 0.33
RAB9A P51151 1/20 0.33
GRM7 Q14831 1/20 0.33
F2 P00734 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
TRPA1 O75762 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27788150 0.78 DPP4 (0.41) HTR2ATAAR1DPP4HRH1F2
SCHEMBL18245682 0.78 TAAR1 (0.39) HTR2ATAAR1HRH1TRPA1LMNA
SCHEMBL7737279 0.73 DPP4 (0.38) KCNH2HTR2ATAAR1DPP4HRH1
SCHEMBL8975316 0.73 KCNH2 (0.40) KCNH2HTR2ATAAR1DPP4ALDH1A1
SCHEMBL9671686 0.71 KCNH2 (0.43) KCNH2HTR2ATAAR1ALDH1A1HRH1
SCHEMBL11192797 0.69 ALDH1A1 (0.71) ALDH1A1MAPK1HTTLMNA
SCHEMBL10728954 0.69 DPP4 (0.38) KCNH2HTR2ATAAR1DPP4HRH1
SCHEMBL1110900 0.69 TSHR (0.41) KCNH2DPP4TSHRF2MAPK1
SCHEMBL6250857 0.67 DPP4 (0.41) HTR2ATAAR1DPP4HRH1TSHR
SCHEMBL14300755 0.67 APP (0.52) KCNH2HTR2AALDH1A1MTORRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407096-B1 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS TORAY INDUSTRIES, INC. (JP) 2002-06-18 US disclosed
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
EP-1028113-A1 FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF TORAY INDUSTRIES, INC. (JP) 2000-08-16 EP disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed