SCHEMBL7736618

SCHEMBL7736618

CN(C=N)Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.56
ALDH1A1 P00352 2/20 0.56
AOC3 Q16853 1/20 0.52
CYP2C19 P33261 1/20 0.46
CARM1 Q86X55 1/20 0.45
PRMT6 Q96LA8 1/20 0.45
PRMT8 Q9NR22 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
LMNA P02545 2/20 0.44
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
MAOB P27338 2/20 0.44
ADRA2B P18089 1/20 0.44
ADRA2C P18825 1/20 0.44
SLC6A2 P23975 1/20 0.44
HTR2A P28223 1/20 0.44
SLC6A4 P31645 1/20 0.44
ADRA1A P35348 1/20 0.44
OPRK1 P41145 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4528866 0.79 TSHR (0.58) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL967209 0.77 TSHR (0.56) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL3239638 0.77 TSHR (0.56) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL1536053 0.77 TSHR (0.56) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL18618721 0.76 TSHR (0.54) TSHRALDH1A1AOC3CYP2C19CARM1
Hydrochloric Acid SCHEMBL9344078 0.76 TSHR (0.54) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL23335699 0.74 TSHR (0.52) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL18811850 0.74 TSHR (0.52) TSHRALDH1A1AOC3CYP2C19CARM1
Ethyne SCHEMBL1921084 0.74 TSHR (0.52) TSHRALDH1A1AOC3CYP2C19CARM1
SCHEMBL27329687 0.74 ALDH1A1 (0.52) TSHRALDH1A1AOC3CYP2C19CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403633-B2 USEFUL ANTIANGIOGENIC, ANTIARTHRITIC, ANTIINFLAMMATORY, ANTIRESTENOTIC, ANTIINVASIVE, ANTIMETASTIC, ANTIOSTEOPOROTIC, ANTIRETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC TREATMENT AGENTS 3-DIMENSIONAL PHARMACEUTICALS, INC. 2002-06-11 US claimed