Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7744212 | 0.99 | CYP19A1 (0.35) | CYP19A1CYP11B1CYP11B2HRH3FNTA | |
| SCHEMBL7744111 | 0.81 | HRH3 (0.37) | CYP19A1CYP11B1CYP11B2HRH3IDO1 | |
| SCHEMBL7744150 | 0.81 | HRH3 (0.37) | CYP19A1CYP11B1CYP11B2HRH3IDO1 | |
| SCHEMBL8481060 | 0.73 | CYP19A1 (0.34) | CYP19A1HRH3FNTAFNTBKCNH2 | |
| SCHEMBL7836006 | 0.73 | FNTA (0.53) | CYP19A1FNTAFNTBKCNH2 | |
| Hydrochloric Acid SCHEMBL8483235 | 0.72 | CYP19A1 (0.34) | CYP19A1HRH3FNTAFNTB | |
| SCHEMBL5552211 | 0.72 | HRH3 (0.41) | CYP19A1HRH3FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7838781 | 0.72 | FNTA (0.52) | CYP19A1FNTAFNTBKCNH2 | |
| SCHEMBL8486902 | 0.72 | HRH3 (0.39) | CYP19A1CYP11B1CYP11B2HRH3IDO1 | |
| SCHEMBL7746101 | 0.71 | CYP19A1 (0.43) | CYP19A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |