Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 14/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738163 | 0.85 | CYP19A1 (0.45) | HRH3CYP19A1 | |
| SCHEMBL7744094 | 0.80 | CYP19A1 (0.40) | HRH3CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7744230 | 0.74 | CYP19A1 (0.42) | HRH3IDO1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7744150 | 0.74 | HRH3 (0.37) | HRH3IDO1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7744111 | 0.74 | HRH3 (0.37) | HRH3IDO1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7743543 | 0.73 | IDO1 (0.51) | HRH3IDO1CYP19A1 | |
| SCHEMBL7744246 | 0.72 | CYP11B1 (0.40) | HRH3CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7738241 | 0.72 | CYP19A1 (0.36) | HRH3IDO1CYP19A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7744212 | 0.71 | CYP19A1 (0.35) | HRH3IDO1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7134263 | 0.71 | HRH3 (0.46) | HRH3CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |