Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.63 |
| ▸ | PDE1A | P54750 | 7/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ABCC5 | O15440 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.40 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731010 | 0.95 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL7738220 | 0.93 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7738216 | 0.92 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL7731030 | 0.91 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7740245 | 0.89 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7736923 | 0.89 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7737752 | 0.88 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CLMNA | |
| SCHEMBL7740252 | 0.87 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CLMNA | |
| SCHEMBL7738293 | 0.86 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7736922 | 0.85 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |