Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.61 |
| ▸ | PDE1A | P54750 | 9/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 9/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 9/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731010 | 0.87 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7736923 | 0.87 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7740295 | 0.86 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL7738249 | 0.86 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7738220 | 0.85 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7737750 | 0.84 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL7731030 | 0.83 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7736922 | 0.82 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL7737752 | 0.82 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL7740245 | 0.82 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |