Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434840 | 0.76 | KCNN4 (0.41) | CTSLCYP2C19HIF1ASMN1; SMN2KCNN4 | |
| SCHEMBL21632007 | 0.73 | SMN1; SMN2 (0.42) | CTSLMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10972965 | 0.73 | CYP2C19 (0.44) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17582917 | 0.72 | CYP2C19 (0.47) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7566897 | 0.72 | CYP2C19 (0.47) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17582914 | 0.72 | CYP2C19 (0.47) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30753736 | 0.69 | KCNN4 (0.44) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29154383 | 0.69 | KCNN4 (0.44) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11833099 | 0.68 | BCL2L1 (0.46) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4579908 | 0.68 | MIF (0.64) | CYP2C19HIF1AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001002346-A1 | CRYSTALLINE SINGLE DIASTEREOMERS OF 2-CYANO-3-ARYLGLUTARATE ESTERS | SMITHKLINE BEECHAM PLC (GB) | 2001-01-11 | — | — | WO | disclosed |