Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441357 | 0.79 | CCR1 (0.38) | KCNN4CCR1CYP2C19ATMCYP2D6 | |
| SCHEMBL1508237 | 0.77 | MAPT (0.45) | CYP2C19OPRM1ALDH1A1LMNA | |
| SCHEMBL4579908 | 0.76 | MIF (0.64) | KCNN4MIFFFAR1CYP2C19HIF1A | |
| SCHEMBL7738262 | 0.76 | CTSL (0.37) | KCNN4MIFFFAR1CTSLCYP2C19 | |
| SCHEMBL1508086 | 0.76 | CCR1 (0.42) | KCNN4CCR1CYP2C19ATMCYP2D6 | |
| SCHEMBL1508075 | 0.75 | L3MBTL1 (0.35) | KCNN4CCR1CTSLCYP2C19ATM | |
| SCHEMBL3160396 | 0.75 | MIF (0.47) | KCNN4MIFCYP2C19HIF1AKIF11 | |
| SCHEMBL11097461 | 0.74 | FFAR1 (0.41) | KCNN4FFAR1CTSLALDH1A1LMNA | |
| SCHEMBL7566897 | 0.73 | CYP2C19 (0.47) | KCNN4MIFCYP2C19HIF1ASMN1; SMN2 | |
| SCHEMBL29154383 | 0.73 | KCNN4 (0.44) | KCNN4MIFFFAR1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | NEUROSEARCH A/S (DK) | 2007-02-01 | — | — | US | claimed |
| EP-1644332-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Poseidon Pharmaceuticals A/S (DK) | 2006-04-12 | — | — | EP | claimed |
| WO-2005003094-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-01-13 | — | — | WO | claimed |
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | NEUROSEARCH A/S (DK) | 2007-02-01 | — | — | US | disclosed |
| EP-1644332-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Poseidon Pharmaceuticals A/S (DK) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003094-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | KCNC1, KCNN3, KCNA1 | KCNN4 44/4885MIF 4597/4885CCR1 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.