Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MMP1 | P03956 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3197299 | 0.93 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL11758728 | 0.88 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL3209637 | 0.87 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7742610 | 0.86 | MMP1 (0.73) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7742636 | 0.85 | GAA (0.65) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9490019 | 0.85 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL11758823 | 0.85 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL12894669 | 0.84 | MMP1 (0.74) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL28570651 | 0.84 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2678159 | 0.84 | NPC1 (0.77) | NPC1RAB9AKMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| CN-1282319-A | Aminobutanoic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 2001-01-31 | — | — | CN | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| CN-1282319-A | Aminobutanoic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 2001-01-31 | — | — | CN | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |