Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739873 | 0.91 | MMP2 (0.48) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7740288 | 0.85 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7742784 | 0.85 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7742781 | 0.85 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7740289 | 0.85 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7739459 | 0.84 | MMP2 (0.50) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7741060 | 0.84 | MMP2 (0.50) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7739462 | 0.84 | MMP2 (0.50) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7741055 | 0.84 | MMP2 (0.50) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7734874 | 0.82 | MMP2 (0.48) | MMP2MMP9MMP12TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |