Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.57 |
| ▸ | MMP9 | P14780 | 4/20 | 0.57 |
| ▸ | MMP12 | P39900 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740017 | 1.00 | MMP2 (0.57) | MMP2MMP9MMP12NPC1RAB9A | |
| SCHEMBL7739858 | 0.93 | MMP2 (0.69) | MMP2MMP9MMP12NPC1RAB9A | |
| SCHEMBL7739862 | 0.93 | MMP2 (0.69) | MMP2MMP9MMP12NPC1RAB9A | |
| SCHEMBL7740336 | 0.91 | MMP2 (0.57) | MMP2MMP9MMP12RAB9ACTSB | |
| SCHEMBL7740329 | 0.91 | MMP2 (0.57) | MMP2MMP9MMP12RAB9ACTSB | |
| SCHEMBL7734696 | 0.90 | MMP2 (0.48) | MMP2MMP9MMP12 | |
| SCHEMBL7734698 | 0.90 | MMP2 (0.48) | MMP2MMP9MMP12 | |
| SCHEMBL7740514 | 0.90 | MMP2 (0.52) | MMP2MMP9MMP12CTSBCTSL | |
| SCHEMBL7740518 | 0.90 | MMP2 (0.52) | MMP2MMP9MMP12CTSBCTSL | |
| SCHEMBL7741151 | 0.89 | MMP2 (0.55) | MMP2MMP9MMP12NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |