Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739420 | 0.91 | MAPT (0.50) | MAPTNPC1TSHRPDE2ATP53 | |
| SCHEMBL7742335 | 0.89 | MAPT (0.52) | MAPTNPC1RECQLCYP3A4CYP2C9 | |
| SCHEMBL7739350 | 0.87 | KDM4E (0.43) | MAPTHTTKMT2AKDM4EMEN1 | |
| SCHEMBL7740742 | 0.83 | KMT2A (0.50) | MAPTTP53KMT2AKDM4EMEN1 | |
| SCHEMBL7739561 | 0.82 | KDM4E (0.42) | HTTCYP3A4CYP2C9NPSR1KMT2A | |
| SCHEMBL7734611 | 0.77 | POLB (0.40) | MAPTHTTNPSR1KMT2AKDM4E | |
| SCHEMBL7740373 | 0.77 | KMT2A (0.43) | MAPTHTTKMT2AKDM4EMEN1 | |
| SCHEMBL7734767 | 0.75 | KDM4E (0.40) | MAPTHTTTP53BACE1KMT2A | |
| SCHEMBL7742329 | 0.74 | ALDH1A1 (0.52) | MAPTTP53KMT2AKDM4EMEN1 | |
| SCHEMBL7734708 | 0.74 | KMT2A (0.42) | MAPTHTTKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420410-B1 | ADMINISTERING N,N'-SUBSTITUTED BENZIMIDAZOL-2-ONES TO INDUCE APOPTOSIS IN NEOPLASTIC CELLS BUT NOT NORMAL CELLS; ANTICANCER, ANTITUMOR AGENT | CELL PATHWAYS, INC. | 2002-07-16 | — | — | US | disclosed |