Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.62 |
| ▸ | IDO1 | P14902 | 3/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TDO2 | P48775 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | GALR3 | O60755 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14405656 | 1.00 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL12804786 | 0.83 | LRRK2 (0.67) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL12971379 | 0.83 | LRRK2 (0.67) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL12804785 | 0.83 | LRRK2 (0.67) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL16760895 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL3613979 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL3544607 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL5740660 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL1898719 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 | |
| SCHEMBL1898716 | 0.80 | LRRK2 (0.62) | LRRK2IDO1AGTR1POLBTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |