Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.62 |
| ▸ | IDO1 | P14902 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDO2 | P48775 | 1/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740660 | 1.00 | LRRK2 (0.62) | LRRK2IDO1CA1CA2ALDH1A1 | |
| SCHEMBL3613979 | 1.00 | LRRK2 (0.62) | LRRK2IDO1CA1CA2ALDH1A1 | |
| SCHEMBL12971379 | 0.83 | LRRK2 (0.67) | LRRK2IDO1ALDH1A1MAPTAGTR1 | |
| SCHEMBL12804786 | 0.83 | LRRK2 (0.67) | LRRK2IDO1ALDH1A1MAPTAGTR1 | |
| SCHEMBL12804785 | 0.83 | LRRK2 (0.67) | LRRK2IDO1ALDH1A1MAPTAGTR1 | |
| SCHEMBL13714143 | 0.83 | MAOA (0.50) | LRRK2IDO1CA1CA2ALDH1A1 | |
| SCHEMBL14468456 | 0.83 | MAOA (0.50) | LRRK2IDO1CA1CA2ALDH1A1 | |
| SCHEMBL1898719 | 0.80 | LRRK2 (0.62) | LRRK2IDO1ALDH1A1MAPTAGTR1 | |
| SCHEMBL16760895 | 0.80 | LRRK2 (0.62) | LRRK2IDO1ALDH1A1MAPTAGTR1 | |
| SCHEMBL7740292 | 0.80 | LRRK2 (0.62) | LRRK2IDO1ALDH1A1MAPTAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221794-A1 | ISATIN DERIVATIVES | KING SAUD UNIVERSITY (SA) | 2021-07-22 | — | — | US | claimed |
| CN-102295647-B | All-alkyl substituted triindenyl cyclopi trimeric-indole derivative and preparation method thereof | UNIV EAST CHINA NORMAL | 2013-07-17 | — | — | CN | claimed |
| CN-102295647-A | All-alkyl substituted triindenyl cyclopi trimeric-indole derivative and preparation method thereof | — | 2011-12-28 | — | — | CN | claimed |
| EP-0503349-B1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-01-04 | — | — | EP | claimed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | claimed |
| EP-0503349-A1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-09-16 | — | — | EP | claimed |
| US-12319674-B2 | Isatin derivatives | KING SAUD UNIVERSITY (SA) | 2025-06-03 | — | — | US | disclosed |
| US-20240239773-A1 | ISATIN DERIVATIVES | KING SAUD UNIVERSITY (SA) | 2024-07-18 | — | — | US | disclosed |
| CN-117945979-A | Isatin derivative, preparation method thereof and application thereof in preparation of plant antibacterial drugs | 陕西师范大学 | 2024-04-30 | — | — | CN | disclosed |
| US-11945809-B2 | Isatin derivatives | KING SAUD UNIVERSITY (SA) | 2024-04-02 | — | — | US | disclosed |
| US-20230357213-A1 | ISATIN DERIVATIVES | KING SAUD UNIVERSITY (SA) | 2023-11-09 | — | — | US | disclosed |
| US-20210221794-A1 | ISATIN DERIVATIVES | KING SAUD UNIVERSITY (SA) | 2021-07-22 | — | — | US | disclosed |
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| WO-2006101937-A1 | ACYLHYDRAZONES AS KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-28 | — | — | WO | disclosed |
| US-6479528-B1 | Methods for inhibiting or reversing tau filament formation polymerization | NEURONAUTICS, INC. | 2002-11-12 | — | — | US | disclosed |
| WO-2002060373-A2 | INDOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS | INSIGHT STRATEGY AND MARKETING LTD (IL) | 2002-08-08 | — | — | WO | disclosed |
| EP-0503349-B1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-01-04 | — | — | EP | disclosed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | disclosed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | disclosed |
| EP-0503349-A1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357213-A1 | ISATIN DERIVATIVES | HASPIN, BRCA1, VHL | LRRK2 4414/4885IDO1 280/4885CA1 4228/4885 |
| US-12319674-B2 | Isatin derivatives | HASPIN, BRCA1, VHL | LRRK2 4414/4885IDO1 280/4885CA1 4228/4885 |
| US-20240239773-A1 | ISATIN DERIVATIVES | HASPIN, BRCA1, VHL | LRRK2 4414/4885IDO1 280/4885CA1 4228/4885 |
| US-20210221794-A1 | ISATIN DERIVATIVES | HASPIN, MCL1, BRCA1 | LRRK2 622/4885IDO1 826/4885CA1 248/4885 |
| US-11945809-B2 | Isatin derivatives | HASPIN, BRCA1, VHL | LRRK2 4414/4885IDO1 280/4885CA1 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.