Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392111 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL8539989 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL11281722 | 0.95 | PDE4B (0.70) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL3171960 | 0.91 | PDE4B (0.79) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL6160043 | 0.88 | HDAC8 (0.72) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL7314253 | 0.87 | GSK3B (0.72) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL4082864 | 0.87 | PDE4B (0.86) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL9522917 | 0.86 | HDAC8 (0.69) | HDAC8HDAC1PDE4BMAPTNPC1 | |
| SCHEMBL7993440 | 0.86 | HDAC8 (0.69) | HDAC8HDAC1PDE4BGSK3BMAPT | |
| SCHEMBL3104200 | 0.86 | PDE4B (0.90) | HDAC8HDAC1PDE4BGSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |