Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 3/20 | 0.39 |
| ▸ | MTHFD2 | P13995 | 4/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2799009 | 0.86 | MAPT (0.48) | KDM4ERXFP1SCN9AF12MAPT | |
| SCHEMBL34464199 | 0.83 | SCN9A (0.42) | KDM4ERXFP1SCN9AMTHFD2SRC | |
| SCHEMBL2505488 | 0.79 | PARP1 (0.42) | KDM4ERXFP1SCN9AF12MAPT | |
| SCHEMBL20738661 | 0.77 | KDM4E (0.41) | KDM4ERXFP1SCN9ASRCMAPT | |
| SCHEMBL2795751 | 0.75 | PARP1 (0.51) | KDM4ERXFP1F12MAPTMAPK1 | |
| SCHEMBL8485777 | 0.75 | CYP2C19 (0.39) | SRCEGFR | |
| SCHEMBL12321214 | 0.74 | MTHFD2 (0.61) | MTHFD2HPGDMAPK1 | |
| SCHEMBL2792908 | 0.73 | DDB1 (0.43) | KDM4EMAPTMAPK1 | |
| SCHEMBL31214426 | 0.72 | SRC (0.35) | KDM4ERXFP1SCN9AMTHFD2SRC | |
| SCHEMBL13654278 | 0.72 | SRC (0.35) | KDM4ERXFP1SCN9ASRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414157-B1 | COMPOUNDS HAVING HIGH AFFINITY FOR 5-HT1B AND 5-HT1C SEROTONIN RECEPTOR; ANTIDEPRESSANTS | ABBOTT LABORATORIES | 2002-07-02 | — | — | US | disclosed |