Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25916815 | 0.84 | LMNA (0.58) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| SCHEMBL6262874 | 0.84 | LMNA (0.58) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| SCHEMBL7741620 | 0.84 | LMNA (0.58) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| SCHEMBL9656176 | 0.82 | TDP1 (0.60) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| SCHEMBL1201655 | 0.82 | TDP1 (0.60) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| Deoxyglucose SCHEMBL3019708 | 0.80 | LMNA (0.50) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| Deoxyglucose SCHEMBL2065929 | 0.80 | LMNA (0.50) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| Deoxyglucose SCHEMBL4480352 | 0.80 | LMNA (0.50) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| Deoxyglucose SCHEMBL148114 | 0.80 | LMNA (0.50) | LMNAL3MBTL1USP2SLCO1B1TDP1 | |
| Deoxyglucose SCHEMBL10386937 | 0.80 | LMNA (0.50) | LMNAL3MBTL1USP2SLCO1B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423834-B1 | CONDENSATION WITH THIOHYDROXAMIC ACID; DECARBOXYLATION, DEBLOCKING | THE SCRIPPS RESEARCH INSTITUTE | 2002-07-23 | — | — | US | claimed |
| EP-0674706-B1 | KDO ALDOLASE AND CONDENSATION REACTIONS EMPLOYED THEREWITH | SCRIPPS RESEARCH INST (US) | 1999-06-09 | — | — | EP | claimed |