Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP12 | P39900 | 5/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | ASAH2 | Q9NR71 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741004 | 1.00 | MMP2 (0.43) | MMP2MMP12MMP9PPARGASAH2 | |
| SCHEMBL7734661 | 0.85 | MMP2 (0.47) | MMP2MMP12MMP9 | |
| SCHEMBL7734657 | 0.85 | MMP2 (0.47) | MMP2MMP12MMP9 | |
| SCHEMBL7739627 | 0.84 | MMP2 (0.43) | MMP2MMP12PPARGASAH2FFAR1 | |
| SCHEMBL7739631 | 0.84 | MMP2 (0.43) | MMP2MMP12PPARGASAH2FFAR1 | |
| SCHEMBL7742443 | 0.83 | MMP2 (0.53) | MMP2MMP12MMP9 | |
| SCHEMBL7742448 | 0.83 | MMP2 (0.53) | MMP2MMP12MMP9 | |
| SCHEMBL7735312 | 0.82 | PLG (0.39) | MMP2MMP12ITGB1ITGA4 | |
| SCHEMBL7735314 | 0.82 | PLG (0.39) | MMP2MMP12ITGB1ITGA4 | |
| SCHEMBL7734969 | 0.80 | MMP2 (0.54) | MMP2MMP12MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |