Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 0.79 |
| ▸ | PDE4A | P27815 | 10/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748803 | 0.96 | TNF (0.86) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6456876 | 0.89 | TNF (0.63) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29441534 | 0.89 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL825490 | 0.86 | TNF (0.71) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7746332 | 0.84 | TNF (0.81) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7746632 | 0.84 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23000623 | 0.84 | PDE4A (0.80) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14528950 | 0.82 | TNF (0.64) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23000601 | 0.82 | PDE4B (0.75) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23392625 | 0.81 | PDE4A (0.71) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |