Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 13/20 | 0.81 |
| ▸ | PDE4A | P27815 | 8/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741527 | 0.96 | TNF (0.88) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6099935 | 0.88 | PDE4A (0.74) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7741538 | 0.84 | TNF (0.79) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6095763 | 0.81 | TNF (0.63) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7847569 | 0.81 | TNF (0.63) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7746632 | 0.81 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23000623 | 0.81 | PDE4A (0.80) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7748803 | 0.81 | TNF (0.86) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1194579 | 0.80 | PDE4B (0.74) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7741608 | 0.79 | TNF (0.88) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |