SCHEMBL7741792

SCHEMBL7741792

COc1ccc2cc(/C(O)=C/C(C)=O)ccc2c1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCEH1 Q6PIU2 9/20 0.47
CYP19A1 P11511 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
ALDH1A1 P00352 2/20 0.40
RXFP1 Q9HBX9 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
LMNA P02545 2/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7741795 1.00 NCEH1 (0.47) NCEH1CYP19A1CYP11B1CYP11B2PDE4A
SCHEMBL8845848 0.86 NCEH1 (0.44) NCEH1ALDH1A1RXFP1LMNAMAPT
SCHEMBL8845854 0.86 NCEH1 (0.44) NCEH1ALDH1A1RXFP1LMNAMAPT
SCHEMBL8164689 0.83 CA12 (0.57) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL7736295 0.83 NCEH1 (0.53) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL4674412 0.79 NCEH1 (0.52) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL11806099 0.78 NCEH1 (0.49) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL7469108 0.78 CYP1A2 (0.65) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL7772381 0.77 MEN1 (0.51) NCEH1CYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL7742063 0.76 KDM4E (0.65) PDE4APDE4BPDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37813-E1 Process for the synthesis of nabumetone HONEYWELL INTERNATIONAL INC. 2002-08-06 US claimed
EP-0792860-B1 Process for the synthesis of nabumetone ALFA CHEM ITAL (IT) 2001-09-12 EP claimed
US-5750793-A REACTING ACETYL BROMO METHOXYNAPHTHALENE WITH ALKYL ACETATE FOLLOWED BY CATALYTIC HYDROGENATION ALFA CHEMICALS ITALIANA S.P.A. (IT) 1998-05-12 US claimed
EP-0792860-A1 Process for the synthesis of nabumetone ALFA CHEMICALS ITALIANA S.p.A. (IT) 1997-09-03 EP claimed
US-RE37813-E1 Process for the synthesis of nabumetone HONEYWELL INTERNATIONAL INC. 2002-08-06 US disclosed
US-RE37813-E1 Process for the synthesis of nabumetone HONEYWELL INTERNATIONAL INC. 2002-08-06 US disclosed
EP-0792860-B1 Process for the synthesis of nabumetone ALFA CHEM ITAL (IT) 2001-09-12 EP disclosed
US-5750793-A REACTING ACETYL BROMO METHOXYNAPHTHALENE WITH ALKYL ACETATE FOLLOWED BY CATALYTIC HYDROGENATION ALFA CHEMICALS ITALIANA S.P.A. (IT) 1998-05-12 US disclosed
US-5750793-A REACTING ACETYL BROMO METHOXYNAPHTHALENE WITH ALKYL ACETATE FOLLOWED BY CATALYTIC HYDROGENATION ALFA CHEMICALS ITALIANA S.P.A. (IT) 1998-05-12 US disclosed
EP-0792860-A1 Process for the synthesis of nabumetone ALFA CHEMICALS ITALIANA S.p.A. (IT) 1997-09-03 EP disclosed
EP-0792860-A1 Process for the synthesis of nabumetone ALFA CHEMICALS ITALIANA S.p.A. (IT) 1997-09-03 EP disclosed