Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.60 |
| ▸ | CTSV | O60911 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | DHODH | Q02127 | 3/20 | 0.57 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.56 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713124 | 0.88 | MRGPRX4 (0.53) | MRGPRX4NR4A2CTSVCTSLDHODH | |
| SCHEMBL17796988 | 0.84 | RXRA (0.61) | DHODHSMN1; SMN2 | |
| SCHEMBL6799282 | 0.84 | MCL1 (0.63) | NR4A2DHODHMAOBSRD5A2MCL1 | |
| SCHEMBL7080517 | 0.82 | P2RY14 (0.60) | MRGPRX4NR4A2CTSVCTSLMAOB | |
| Hydrochloric Acid SCHEMBL9222333 | 0.82 | MCL1 (0.62) | NR4A2DHODHMAOBSRD5A2MCL1 | |
| SCHEMBL11593773 | 0.82 | P2RY14 (0.60) | MRGPRX4NR4A2CTSVCTSLMAOB | |
| Hydrochloric Acid SCHEMBL9222328 | 0.81 | P2RY14 (0.59) | MRGPRX4NR4A2CTSVCTSLMAOB | |
| SCHEMBL5112581 | 0.80 | MAOB (0.57) | MRGPRX4NR4A2MAOBMCL1PTGER1 | |
| SCHEMBL1746678 | 0.80 | FFAR1 (0.76) | — | |
| SCHEMBL379281 | 0.79 | MAOB (0.67) | MRGPRX4NR4A2CYP4F2CYP4A11MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091736-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1091736-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001382-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |