Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | TP53 | P04637 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | C1R | P00736 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29404641 | 1.00 | MAPT (0.67) | MAPTTP53SMN1; SMN2KMT2AC1R | |
| SCHEMBL1832604 | 0.86 | NPC1 (0.61) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL171055 | 0.86 | TOP2A (0.62) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL29504749 | 0.86 | TOP2A (0.62) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL15976158 | 0.85 | TOP2A (0.58) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL10852717 | 0.85 | MAPT (0.52) | MAPTTP53SMN1; SMN2KMT2AC1R | |
| SCHEMBL12854009 | 0.84 | TOP2A (0.60) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL10415479 | 0.83 | MAPT (0.62) | MAPTTP53SMN1; SMN2KMT2AC1R | |
| SCHEMBL824375 | 0.82 | NPC1 (0.69) | MAPTTP53SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL29531707 | 0.82 | NPC1 (0.69) | MAPTTP53SMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135923-B | Composition for cover layer of organic electroluminescent device and organic electroluminescent device comprising same | 伊爱尔安株式会社 | 2023-09-12 | — | — | CN | disclosed |
| CN-114105998-A | Composition for capping layer of organic electroluminescent device and organic electroluminescent device comprising same | 伊爱尔安株式会社 | 2022-03-01 | — | — | CN | disclosed |
| CN-108602812-B | Bicyclic hydroxamic acids useful as inhibitors of histone deacetylase activity in mammals | 坎塞拉有限公司 | 2021-11-02 | — | — | CN | disclosed |
| EP-3394052-B1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2021-07-28 | — | — | EP | disclosed |
| CN-113135923-A | Composition for capping layer of organic electroluminescent device and organic electroluminescent device comprising same | 伊爱尔安株式会社 | 2021-07-20 | — | — | CN | disclosed |
| US-10654814-B2 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity | KANCERA AB (SE) | 2020-05-19 | — | — | US | disclosed |
| US-20190284147-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2019-09-19 | — | — | US | disclosed |
| CN-109457268-A | A kind of method of electro-catalysis benzamide compound synthesis benzoxazoles | 福建医科大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-109369555-A | A kind of method of microwave radiation benzamide compound synthesis benzoxazoles in water phase | 福建医科大学 | 2019-02-22 | — | — | CN | disclosed |
| CN-109265409-A | A kind of synthetic method of the benzoxazoles that 2- replaces and benzothiazole and its derivative that 2- replaces | 重庆医科大学 | 2019-01-25 | — | — | CN | disclosed |
| CN-109180590-A | A method of Benzoheterocyclic compounds are quickly prepared using physical grinding method under room temperature solvent-free | 福建医科大学 | 2019-01-11 | — | — | CN | disclosed |
| EP-3394052-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | Kancera AB (SE) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017108282-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2017-06-29 | — | — | WO | disclosed |
| US-8697872-B2 | Boron compounds and uses thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2014-04-15 | — | — | US | disclosed |
| US-20120253044-A1 | Boron Compounds and Uses Thereof | WANG, SUNING (CA) | 2012-10-04 | — | — | US | disclosed |
| EP-1039915-A4 | CYCLIC PHOSPHONATE ESTER INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2001-02-14 | — | — | EP | disclosed |
| EP-1039915-A1 | CYCLIC PHOSPHONATE ESTER INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999021564-A1 | CYCLIC PHOSPHONATE ESTER INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654814-B2 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity | HDAC1, HDAC11, HDAC10 | MAPT 1282/4885TP53 1424/4885SMN1; SMN2 983/4885 |
| US-20190284147-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | HDAC1, HDAC11, HDAC10 | MAPT 1282/4885TP53 1424/4885SMN1; SMN2 983/4885 |
| US-20120253044-A1 | Boron Compounds and Uses Thereof | BRI3BP, BRSK1, BROX | MAPT 1597/4885TP53 2830/4885SMN1; SMN2 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.