SCHEMBL7743342

SCHEMBL7743342

CCC(O)c1cccc(-c2cccc(OC)c2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.54
CHRM2 P08172 1/20 0.49
CHRM1 P11229 1/20 0.49
CHRM3 P20309 1/20 0.49
HDAC4 P56524 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
LMNA P02545 1/20 0.47
FAAH O00519 1/20 0.46
CTSA P10619 1/20 0.46
AKR1C3 P42330 1/20 0.46
AKR1C2 P52895 1/20 0.46
CYP17A1 P05093 1/20 0.46
CYP1A1 P04798 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2E1 P05181 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2A6 P11509 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL801059 0.90 AOC3 (0.66) AOC3L3MBTL1CHRM2CHRM1CHRM3
SCHEMBL3920742 0.90 AOC3 (0.66) AOC3L3MBTL1CHRM2CHRM1CHRM3
SCHEMBL23346006 0.83 HDAC4 (0.53) AOC3L3MBTL1HDAC4HDAC8CTSA
SCHEMBL17795044 0.78 LMNA (0.52) LMNAFAAHCTSATSHR
SCHEMBL14815652 0.78 FYN (0.48) HDAC4HDAC8LMNAFAAHCYP17A1
SCHEMBL487170 0.78 CYP1A1 (0.53) HDAC4HDAC8CTSAAKR1C3AKR1C2
SCHEMBL3907003 0.77 AOC3 (0.62) AOC3L3MBTL1CHRM2CHRM1CHRM3
SCHEMBL15195819 0.77 AOC3 (0.62) AOC3L3MBTL1CHRM2CHRM1CHRM3
SCHEMBL13850026 0.77 AOC3 (0.62) AOC3L3MBTL1CHRM2CHRM1CHRM3
SCHEMBL11595350 0.76 LMNA (0.70) AOC3L3MBTL1HDAC4HDAC8LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091736-A4 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2001-10-24 EP disclosed
EP-1091736-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2001-04-18 EP disclosed
WO-2000001382-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 2000-01-13 WO disclosed