Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743528 | 1.00 | HDAC8 (0.54) | HDAC8PTPN1NR1D1OPRM1OPRD1 | |
| SCHEMBL4480030 | 0.87 | NR1D1 (0.61) | HDAC8PTPN1NR1D1ACE | |
| SCHEMBL29409306 | 0.87 | NR1D1 (0.61) | HDAC8PTPN1NR1D1ACE | |
| SCHEMBL6650752 | 0.87 | NR1D1 (0.61) | HDAC8PTPN1NR1D1ACE | |
| SCHEMBL7746006 | 0.85 | PTPN1 (0.56) | HDAC8PTPN1NR1D1OPRM1OPRD1 | |
| SCHEMBL7746008 | 0.85 | PTPN1 (0.56) | HDAC8PTPN1NR1D1OPRM1OPRD1 | |
| SCHEMBL7743681 | 0.81 | PTPN1 (0.54) | HDAC8PTPN1 | |
| SCHEMBL7743679 | 0.81 | PTPN1 (0.54) | HDAC8PTPN1 | |
| SCHEMBL2078707 | 0.81 | ESR2 (0.51) | HDAC8PTPN1NR1D1 | |
| SCHEMBL29409301 | 0.78 | NR1D1 (0.68) | NR1D1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |