Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 19/20 | 0.61 |
| ▸ | FNTB | P49356 | 19/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743536 | 0.92 | FNTA (0.53) | FNTAFNTBKCNH2PGGT1BCYP3A4 | |
| SCHEMBL7540064 | 0.89 | FNTA (0.60) | FNTAFNTBKCNH2PGGT1BCYP3A4 | |
| SCHEMBL7536075 | 0.83 | FNTA (0.52) | FNTAFNTBPGGT1B | |
| SCHEMBL7477932 | 0.83 | FNTA (0.56) | FNTAFNTBPGGT1B | |
| SCHEMBL7738318 | 0.81 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL8479891 | 0.81 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL7533614 | 0.80 | FNTA (0.59) | FNTAFNTBPGGT1B | |
| SCHEMBL7533105 | 0.80 | FNTA (0.51) | FNTAFNTBPGGT1B | |
| SCHEMBL7738308 | 0.78 | FNTA (0.51) | FNTAFNTBPGGT1B | |
| SCHEMBL7738301 | 0.78 | FNTA (0.51) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |