Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 18/20 | 0.53 |
| ▸ | FNTB | P49356 | 18/20 | 0.53 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NRAS | P01111 | 1/20 | 0.45 |
| ▸ | HRAS | P01112 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743601 | 0.92 | FNTA (0.61) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7744257 | 0.86 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL7540064 | 0.82 | FNTA (0.60) | FNTAFNTBPGGT1BKCNH2CYP3A4 | |
| SCHEMBL7744133 | 0.81 | FNTA (0.47) | FNTAFNTBPGGT1B | |
| SCHEMBL7744139 | 0.81 | FNTA (0.47) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8483577 | 0.81 | FNTA (0.46) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8483580 | 0.81 | FNTA (0.46) | FNTAFNTBPGGT1B | |
| SCHEMBL8480643 | 0.79 | CYP11B1 (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL8480647 | 0.79 | CYP11B1 (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL7477932 | 0.78 | FNTA (0.56) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |