Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | NMBR | P28336 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742501 | 0.93 | TACR1 (0.46) | TACR1MEN1KMT2ASMN1; SMN2CCKBR | |
| SCHEMBL7743627 | 0.91 | TACR1 (0.51) | TACR1MEN1KMT2ASMN1; SMN2CCKBR | |
| SCHEMBL7743028 | 0.84 | TACR1 (0.54) | TACR1MEN1KMT2ASMN1; SMN2NMBR | |
| SCHEMBL7745638 | 0.84 | TACR1 (0.50) | TACR1MEN1KMT2ASMN1; SMN2CCKBR | |
| SCHEMBL7742410 | 0.82 | KMT2A (0.52) | TACR1KMT2ACCKBRNMBRALDH1A1 | |
| SCHEMBL7743281 | 0.80 | TACR1 (0.49) | TACR1KMT2ACCKBR | |
| SCHEMBL7743652 | 0.79 | SSTR2 (0.47) | TACR1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7743569 | 0.78 | TACR1 (0.49) | TACR1CCKBRNMBR | |
| SCHEMBL8748207 | 0.78 | BRS3 (0.55) | TACR1NMBR | |
| SCHEMBL7743651 | 0.78 | TACR1 (0.55) | TACR1MEN1KMT2ASMN1; SMN2CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | claimed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | claimed |
| WO-1997006803-A1 | 2-ACYLAMINOPROPANAMIDES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | claimed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | claimed |