Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | BRS3 | P32247 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961393 | 0.90 | HRH3 (0.43) | HRH3BRS3HRH1HTR1BHRH4 | |
| SCHEMBL7505077 | 0.90 | LOXL2 (0.49) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL7571253 | 0.85 | HRH3 (0.47) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL7468902 | 0.84 | HRH3 (0.48) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL7129739 | 0.84 | BRS3 (0.52) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL8498703 | 0.84 | BRS3 (0.49) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL10588302 | 0.84 | BRS3 (0.49) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL8121737 | 0.83 | BRS3 (0.49) | HRH3BRS3LOXL2TYMPGRIN1 | |
| Hydrochloric Acid SCHEMBL6949148 | 0.82 | HRH3 (0.47) | HRH3BRS3LOXL2TYMPGRIN1 | |
| SCHEMBL7743907 | 0.82 | DAO (0.47) | HRH1HTR1BHRH4DAONSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |