Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631761 | 0.90 | PDE4A (0.42) | PDE4ANOS2ALDH1A1LMNAHPGD | |
| SCHEMBL3387177 | 0.75 | PDE4A (0.50) | PDE4ALMNATDP1L3MBTL1MAPT | |
| SCHEMBL31687319 | 0.74 | NOS2 (0.42) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL16913747 | 0.74 | NOS2 (0.34) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL30555739 | 0.73 | — | — | |
| SCHEMBL6077735 | 0.70 | NOS2 (0.42) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL888750 | 0.69 | HPGD (0.45) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL888758 | 0.69 | HPGD (0.45) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL8086658 | 0.69 | HPGD (0.45) | NOS2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL9484977 | 0.68 | NOS2 (0.48) | NOS2ALDH1A1HPGDTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161231-A2 | METHOD OF INHIBITING A CHAPERONE PROTEIN | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053169-A2 | METHOD OF INHIBITING A CHAPERONE PROTEIN | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-09-14 | — | — | WO | disclosed |