Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327025 | 0.84 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8328029 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7743993 | 0.82 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7342539 | 0.81 | PDE4B (0.81) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7443177 | 0.81 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7437810 | 0.80 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7437791 | 0.79 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7341550 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7440927 | 0.78 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7431229 | 0.77 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939633-A4 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIV PITTSBURGH (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0939633-A1 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIVERSITY OF PITTSBURGH (US) | 1999-09-08 | — | — | EP | disclosed |
| US-5849774-A | Treatment of sepsis-induced acute renal failure | UNIVERSITY OF PITTSBURGH (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1998000135-A1 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIVERSITY OF PITTSBURGH (US) | 1998-01-08 | — | — | WO | disclosed |