Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327025 | 0.91 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7342539 | 0.89 | PDE4B (0.81) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8328029 | 0.89 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7443177 | 0.87 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7341550 | 0.86 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7431229 | 0.86 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7437810 | 0.86 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7437791 | 0.85 | PDE4B (0.89) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL11625752 | 0.84 | PDE4B (0.72) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7743949 | 0.82 | PDE4B (0.72) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-0939633-A4 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIV PITTSBURGH (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0939633-A1 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIVERSITY OF PITTSBURGH (US) | 1999-09-08 | — | — | EP | disclosed |
| US-5849774-A | Treatment of sepsis-induced acute renal failure | UNIVERSITY OF PITTSBURGH (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1998000135-A1 | TREATMENT OF SEPSIS-INDUCED ACUTE RENAL FAILURE AND RENAL VASOCONSTRICTION AND CATECHOLAMINE-INDUCED RENAL AND MESENTERIC VASOCONSTRICTION | UNIVERSITY OF PITTSBURGH (US) | 1998-01-08 | — | — | WO | disclosed |