Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761364 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10651830 | 0.86 | KDM4E (0.67) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10618267 | 0.85 | KDM4E (0.76) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10423524 | 0.85 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL21241423 | 0.85 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| Methylamine SCHEMBL10474969 | 0.82 | PDE3B (0.95) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10621089 | 0.82 | KDM4E (0.71) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3723997 | 0.82 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3723998 | 0.82 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10932177 | 0.81 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001011933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A 7-(2-AMINOETHYL)-BENZOTHIAZOLONE AND A PDE4 INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2001-02-22 | — | — | WO | claimed |