Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 3/20 | 0.39 |
| ▸ | FNTB | P49356 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7746024 | 0.99 | TAAR1 (0.46) | TAAR1BRS3TRPM5FNTAFNTB | |
| SCHEMBL3523908 | 0.75 | TAAR1 (0.53) | TAAR1BRS3TRPM5FNTAFNTB | |
| SCHEMBL10588302 | 0.74 | BRS3 (0.49) | BRS3HRH3 | |
| Hydrochloric Acid SCHEMBL7744227 | 0.73 | CES1 (0.50) | BRS3ALDH1A1ALOX15TSHR | |
| SCHEMBL7919393 | 0.72 | BRS3 (0.62) | BRS3HRH3 | |
| SCHEMBL7743707 | 0.72 | CYP1A2 (0.45) | BRS3ALDH1A1HRH3TSHR | |
| SCHEMBL7744106 | 0.72 | FNTA (0.60) | FNTAFNTB | |
| SCHEMBL23567776 | 0.71 | HDAC1 (0.57) | TAAR1ALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL8498703 | 0.71 | BRS3 (0.49) | BRS3ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL7129739 | 0.71 | BRS3 (0.52) | BRS3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |