Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | BRS3 | P32247 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743677 | 0.81 | MAPT (0.49) | BRS3TSHRKDM4EMAPT | |
| SCHEMBL7468902 | 0.75 | HRH3 (0.48) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7571253 | 0.74 | HRH3 (0.47) | CYP1A2RECQLBRS3HRH3TYMP | |
| Hydrochloric Acid SCHEMBL6949148 | 0.74 | HRH3 (0.47) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7919393 | 0.73 | BRS3 (0.62) | BRS3HRH3GRIN1GRIN2BCYP11B1 | |
| SCHEMBL8498703 | 0.73 | BRS3 (0.49) | CYP1A2RECQLBRS3HRH3TYMP | |
| SCHEMBL10588302 | 0.73 | BRS3 (0.49) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7129739 | 0.73 | BRS3 (0.52) | BRS3HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL7505077 | 0.73 | LOXL2 (0.49) | CYP1A2BRS3HRH3TYMPGRIN1 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.72 | BRS3 (0.61) | BRS3HRH3GRIN1GRIN2BCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |