Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.58 |
| ▸ | FNTB | P49356 | 11/20 | 0.58 |
| ▸ | PGGT1B | P53609 | 8/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8479762 | 0.99 | FNTA (0.57) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7744226 | 0.84 | FNTA (0.54) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7744148 | 0.80 | FNTA (0.54) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7046791 | 0.76 | FNTA (0.64) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7738240 | 0.76 | FNTA (0.57) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7744209 | 0.75 | FNTA (0.56) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7047035 | 0.74 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL2786255 | 0.73 | CYP11B1 (0.71) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8487144 | 0.73 | PRKAA2 (0.53) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7738283 | 0.72 | FNTA (0.54) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |