Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.97 |
| ▸ | PDE4A | P27815 | 15/20 | 0.86 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.86 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.86 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381240 | 0.98 | ADORA2B (0.94) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7738354 | 0.98 | ADORA2B (1.00) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381253 | 0.97 | ADORA2B (0.97) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3990422 | 0.96 | ADORA2B (0.94) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5006812 | 0.96 | ADORA2B (0.92) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3186630 | 0.95 | PDE4A (0.94) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381255 | 0.94 | ADORA2B (0.92) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381238 | 0.94 | ADORA2B (0.86) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11361392 | 0.94 | PDE4A (0.91) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381261 | 0.93 | ADORA2B (0.89) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708781-B1 | A 3 ADENOSINE RECEPTOR AGONISTS | USA (US) | 2001-10-04 | — | — | EP | disclosed |
| US-5773423-A | XANTHINE RIBOSIDES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0708781-A1 | A 3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002604-A1 | A3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-01-26 | — | — | WO | disclosed |