Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746647 | 0.94 | KDR (0.41) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7744076 | 0.90 | KDR (0.46) | KDRALDH1A1MAPTRAB9AFLT1 | |
| SCHEMBL7744083 | 0.86 | KDR (0.47) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7739077 | 0.84 | KDR (0.42) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7739074 | 0.82 | KDR (0.53) | KDRRAB9AFLT1FLT4ADORA2A | |
| SCHEMBL7744794 | 0.82 | PKM (0.43) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7744763 | 0.82 | KDM4E (0.46) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7744098 | 0.82 | FLT1 (0.40) | KDRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7744776 | 0.82 | MAPT (0.41) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL7744055 | 0.81 | MEN1 (0.41) | ALDH1A1MAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097147-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | claimed |
| EP-1097147-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-05-09 | — | — | EP | claimed |
| WO-2000002871-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-01-20 | — | — | WO | claimed |