Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 16/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.58 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Siguazodan SCHEMBL12648714 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL149133 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL1024118 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL7744697 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL17224472 | 0.83 | PDE3A (0.50) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL7746515 | 0.81 | PDE3B (0.56) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL7743969 | 0.81 | PDE3B (0.56) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL4459608 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL18522869 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL1024119 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001011933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A 7-(2-AMINOETHYL)-BENZOTHIAZOLONE AND A PDE4 INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2001-02-22 | — | — | WO | claimed |