Siguazodan

Siguazodan

SCHEMBL149133

CN/C(=N/c1ccc(C2=NNC(=O)CC2C)cc1)NC#N

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.67
ALDH1A1 P00352 1/20 0.67
CYP1A2 P05177 1/20 0.67
CYP3A4 P08684 1/20 0.67
ALOX15 P16050 1/20 0.67
TSHR P16473 1/20 0.67
MAPK1 P28482 1/20 0.67
LMNA P02545 1/20 0.67
BLM P54132 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
PDE3B Q13370 16/20 0.58
PDE3A Q14432 16/20 0.58
TNNC1 P63316 1/20 0.58
PDE4A P27815 2/20 0.45
PDE4B Q07343 2/20 0.45
PDE4C Q08493 2/20 0.45
PDE4D Q08499 2/20 0.45
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GPR119 Q8TDV5 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Siguazodan SCHEMBL12648714 1.00 KDM4E (0.67) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL7744694 1.00 KDM4E (0.67) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL1024118 1.00 KDM4E (0.67) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL7744697 1.00 KDM4E (0.67) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL17224472 0.83 PDE3A (0.50) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
SCHEMBL7746515 0.81 PDE3B (0.56) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
SCHEMBL7743969 0.81 PDE3B (0.56) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL4459608 0.80 KDM4E (1.00) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL18522869 0.80 KDM4E (1.00) KDM4EALDH1A1CYP1A2CYP3A4ALOX15
Siguazodan SCHEMBL1024119 0.80 KDM4E (1.00) KDM4EALDH1A1CYP1A2CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2023196821-A2 TARGETING NEUROPOD CELL GUCY2C TO CONTROL VISCERAL PAIN AND APPETITE THOMAS JEFFERSON UNIVERSITY (US) 2023-10-12 WO claimed
WO-2023055751-A1 MIXED SOLVENT HYDROGEL SYSTEM FOR WOUND HEALING UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2023-04-06 WO claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
EP-2704560-B1 ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS TRANSMEDICS INC (US) 2022-04-06 EP claimed
EP-3943092-A2 COMPOSITIONS FOR USE IN INDUCING DIFFERENTIATION OF HUMAN BROWN ADIPOCYTE PROGENITORS Energesis Pharmaceuticals Inc. (US) 2022-01-26 EP claimed
EP-0961616-A4 NON-HORMONAL METHOD OF CONTRACEPTION TRUSTEES OF BOARD OF (US) 2000-11-22 EP claimed
US-6110471-A ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-08-29 US claimed
EP-1028690-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 2000-08-23 EP claimed
WO-2000012076-A9 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2000-08-17 WO claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
WO-2000012076-A1 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-03-09 WO claimed
EP-0961616-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1999-12-08 EP claimed
WO-1999020223-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 1999-04-29 WO claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed
WO-1998010765-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1998-03-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol VNN1, LPL, HMGB1 KDM4E 3388/4885ALDH1A1 2390/4885CYP1A2 3874/4885
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL VNN1, LPL, HMGB1 KDM4E 3388/4885ALDH1A1 2390/4885CYP1A2 3874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.