Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051100 | 0.72 | SLC1A2 (0.39) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7745751 | 0.71 | GRM8 (0.38) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL339954 | 0.70 | ANPEP (0.33) | — | |
| SCHEMBL5053179 | 0.69 | SLC1A2 (0.48) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL5052993 | 0.68 | SLC1A2 (0.44) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL5053034 | 0.67 | CYP2C9 (0.37) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL1313868 | 0.66 | CHRM1 (0.36) | — | |
| SCHEMBL7395896 | 0.64 | SLC1A2 (0.56) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL7357839 | 0.63 | SLC1A2 (0.50) | SLC1A2CYP2C9CYP2C19GRM8GRM6 | |
| SCHEMBL12985560 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001014390-A2 | METABOTROPIC GLUTAMATE RECEPTOR LIGAND DERIVATIVES AS NAALADase INHIBITORS | GUILFORD PHARMACEUTICALS (US) | 2001-03-01 | — | — | WO | disclosed |