Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.38 |
| ▸ | GRM6 | O15303 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | GCLC | P48506 | 1/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | GLUL | P15104 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748019 | 0.92 | GABBR2 (0.39) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL5051100 | 0.87 | SLC1A2 (0.39) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL5053034 | 0.78 | CYP2C9 (0.37) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL7364671 | 0.78 | SLC1A2 (0.44) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL7360984 | 0.76 | GPR84 (0.43) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL7357839 | 0.73 | SLC1A2 (0.50) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL7399439 | 0.73 | SLC1A2 (0.46) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL5053079 | 0.73 | SLC1A2 (0.46) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL5053182 | 0.71 | SLC1A2 (0.47) | GRM8GRM6GRM4CYP2C9CYP2C19 | |
| SCHEMBL7745748 | 0.71 | SLC1A2 (0.38) | GRM8GRM6GRM4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001014390-A2 | METABOTROPIC GLUTAMATE RECEPTOR LIGAND DERIVATIVES AS NAALADase INHIBITORS | GUILFORD PHARMACEUTICALS (US) | 2001-03-01 | — | — | WO | disclosed |