Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 9/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848269 | 0.83 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7855422 | 0.82 | MEN1 (0.47) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7745819 | 0.77 | MEN1 (0.53) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7743110 | 0.77 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7855485 | 0.77 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7855484 | 0.77 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5388594 | 0.77 | MAP2K1 (0.52) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7743118 | 0.75 | MEN1 (0.45) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5677719 | 0.74 | MAP2K1 (0.79) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7737777 | 0.73 | MEN1 (0.45) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002532414-A | — | — | 2002-10-02 | — | — | JP | claimed |
| EP-1140046-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | claimed |