Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 12/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 12/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 12/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983806 | 0.89 | PDE1A (0.68) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL16690970 | 0.88 | PDE1A (0.60) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL7746164 | 0.87 | PDE1A (0.47) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL7746654 | 0.85 | PDE1A (0.50) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL7746112 | 0.83 | PDE1A (0.65) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL7746173 | 0.82 | PDE1A (0.55) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL7746194 | 0.80 | PDE3B (0.52) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL13668874 | 0.79 | PDE1A (0.55) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL15850367 | 0.78 | PDE1A (0.59) | PDE1APDE1BPDE1CPDE3BPDE3A | |
| SCHEMBL16690981 | 0.77 | PDE1A (0.41) | PDE1APDE1BPDE1CPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214996-B1 | SHOWING EXCELLENT BRONCHIOCONSTRICTION INHIBITORY ACTIVITY,USEFUL IN THE PROPHYLAXIS OR TREATNEBT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| US-6005106-A | BRONCHOCONSTRICTOR AGENTS USEFUL IN THE TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| US-5969140-A | AMINOPYRIDINE DERIVATIVES OF NAPHTHALENE FOR TREATMENT OF ASTHMA AND BRONCHOCONSTRICTOR INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0748805-B1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0748805-A1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO., LTD. (JP) | 1996-12-18 | — | — | EP | disclosed |