Sugi Predict

Sugi Predict / Compounds / SCHEMBL7746266

SCHEMBL7746266

SCHEMBL7746266

Nn1cnc(=O)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 1/20 0.43
▸ ALDH1A1 P00352 4/20 0.42
▸ THRB P10828 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ KDM4E B2RXH2 4/20 0.40
▸ HSD17B10 Q99714 3/20 0.40
▸ HPGD P15428 3/20 0.40
▸ P2RX4 Q99571 4/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ RCE1 Q9Y256 1/20 0.36
▸ POLB P06746 1/20 0.35
▸ GLA P06280 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ KMT2A Q03164 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28276224 0.80 KDM4C (0.43) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL7738578 0.76 KDM4C (0.40) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL29352067 0.76 ALDH1A1 (0.43) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL1304538 0.76 ALDH1A1 (0.43) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL7744395 0.76 KDM4C (0.37) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL10514072 0.73 HTT (0.56) ALDH1A1SMN1; SMN2KMT2A
SCHEMBL19707446 0.72 ALDH1A1 (0.50) KDM4CALDH1A1KDM4EP2RX4SMN1; SMN2
SCHEMBL29458571 0.72 USP5 (0.42) KDM4CALDH1A1KDM4EHSD17B10HPGD
SCHEMBL20897493 0.72 P2RX4 (0.42) KDM4CALDH1A1L3MBTL1KDM4EHSD17B10
SCHEMBL14726016 0.72 USP5 (0.42) KDM4CALDH1A1KDM4EHSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20010018518-A1 Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof GAO YUN (US) 2001-08-30 — — US claimed
US-6429311-B2 CHEMICAL INTERMEDIATE FOR HYPOTENSIVE AGENTS, BACTERICIDES, FUNGICIDES, ANTIPYRETICS AND ANTIDEPRESSANTS SEPRACOR INC. 2002-08-06 — — US disclosed
US-20010018518-A1 Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof GAO YUN (US) 2001-08-30 — — US disclosed
US-6184377-B1 ANTIPYRETIC, HYPOTENSIVE, ANTIBACTERIAL, ANTIFUNGAL OR CENTRAL NERVOUS SYSTEM (CNS) ACTIVITY, AS WELL AS THE ABILITY TO INHIBIT ENZYMES SEPRACOR INC. 2001-02-06 — — US disclosed
US-3936453-A 1-Substituted-2-disubstituted aminoquin azolin-4(1h)-ones SANDOZ, INC. (US) 1976-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010018518-A1 Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof NQO2, ASNS, AAAS KDM4C 524/4885ALDH1A1 821/4885THRB 3728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.