SCHEMBL7746475

SCHEMBL7746475

Cc1cc(C#CCc2ccc3c(c2)C(C)(C)CCC3(C)C)ccc1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARG P13631 7/20 0.55
RARB P10826 7/20 0.55
RARA P10276 6/20 0.55
CYP26A1 O43174 5/20 0.55
CYP3A4 P08684 2/20 0.55
CRABP2 P29373 1/20 0.55
RXRA P19793 13/20 0.52
RXRB P28702 6/20 0.52
RXRG P48443 5/20 0.52
CYP26B1 Q9NR63 4/20 0.44
MEN1 O00255 1/20 0.43
ABCB11 O95342 1/20 0.43
ESR1 P03372 1/20 0.43
PGR P06401 1/20 0.43
HTR1A P08908 1/20 0.43
ADRA2A P08913 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
CHRM1 P11229 1/20 0.43
DRD1 P21728 1/20 0.43
TBXA2R P21731 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6378170 0.88 RARB (0.52) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7751295 0.87 RARB (0.51) RARGRARBRARACYP26A1CYP3A4
SCHEMBL6372002 0.85 RARB (0.71) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7746407 0.83 RARB (0.76) RARGRARBRARACYP26A1CYP3A4
Diethanolamine SCHEMBL7753391 0.81 RARB (0.45) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7753443 0.81 RXRA (0.48) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7746467 0.80 RXRA (0.60) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7752077 0.80 RARB (0.55) RARGRARBRARACYP26A1CYP3A4
SCHEMBL7928437 0.80 RARB (0.55) RARGRARBRARACYP26A1CYP3A4
Lithium Ion SCHEMBL7751288 0.80 CYP26A1 (0.44) RARGRARBRARACYP26A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313162-B1 FOR USE IN HUMAN OR VETERINARY MEDICINE SUCH AS DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHHALMOLOGICAL DISORDERS; AND IN COSMETICS CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) GALDERMA (FR) 2001-11-06 US claimed
EP-0832057-B1 DIAROMATIC PROPYNYL OR DIENYL COMPOUNDS CT INTERNAT DE (FR) 2001-01-03 EP claimed
US-6046220-A ADMINISTERING TO THE PATIENT A PROPYNYL OR DIENYL BIAROMATIC COMPOUND TO TREAT A SKIN DISORDER, INFLAMMATORY CONDITIONS, VISION DEFECTS, ALOPECIA, CARDIOVASCULAR DISORDER, CANCER OR PRECANCER AND INSULIN DEPENDANT DIABETES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-04-04 US claimed
US-6313162-B1 FOR USE IN HUMAN OR VETERINARY MEDICINE SUCH AS DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHHALMOLOGICAL DISORDERS; AND IN COSMETICS CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) GALDERMA (FR) 2001-11-06 US disclosed
US-6046220-A ADMINISTERING TO THE PATIENT A PROPYNYL OR DIENYL BIAROMATIC COMPOUND TO TREAT A SKIN DISORDER, INFLAMMATORY CONDITIONS, VISION DEFECTS, ALOPECIA, CARDIOVASCULAR DISORDER, CANCER OR PRECANCER AND INSULIN DEPENDANT DIABETES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-04-04 US disclosed