Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340438 | 0.89 | PLK1 (0.59) | PLK1PLK2 | |
| SCHEMBL15267465 | 0.88 | PLK1 (0.44) | PLK1PLK2SMN1; SMN2 | |
| SCHEMBL21491931 | 0.85 | PLK2 (0.38) | PLK1PLK2SMN1; SMN2 | |
| SCHEMBL21491653 | 0.85 | PLK2 (0.38) | PLK1PLK2SMN1; SMN2 | |
| SCHEMBL21492280 | 0.78 | PLK1 (0.33) | PLK1PLK2 | |
| SCHEMBL21491674 | 0.78 | PLK1 (0.33) | PLK1PLK2 | |
| SCHEMBL6910408 | 0.78 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL11956889 | 0.77 | PLK1 (0.35) | PLK1PLK2 | |
| SCHEMBL12392662 | 0.76 | PLK2 (0.63) | PLK1PLK2 | |
| SCHEMBL21492655 | 0.75 | STK4 (0.36) | PLK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |