Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7747074 | 1.00 | POLB (0.53) | POLBHTTSMN1; SMN2HPGDLMNA | |
| Acetic Acid SCHEMBL916506 | 0.93 | POLB (0.48) | POLBHTTSMN1; SMN2HPGDLMNA | |
| Acetic Acid SCHEMBL916504 | 0.93 | POLB (0.48) | POLBHTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL5571385 | 0.85 | POLB (0.53) | POLBHTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL5571382 | 0.85 | POLB (0.53) | POLBHTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL7743096 | 0.83 | HPGD (0.68) | POLBHTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL7743100 | 0.83 | HPGD (0.68) | POLBHTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL18131646 | 0.82 | POLB (0.40) | POLBHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL18130862 | 0.82 | POLB (0.40) | POLBHTTSMN1; SMN2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL6515894 | 0.82 | HPGD (0.66) | POLBHTTSMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | claimed |
| US-8309609-B2 | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands | ANAMAR AB (SE) | 2012-11-13 | — | — | US | disclosed |