SCHEMBL7747161

SCHEMBL7747161

COC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1

nearest known ligand 0.87

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7747165 1.00 BDKRB2 (0.87) BDKRB2
SCHEMBL7748335 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL7748339 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL7749618 0.93 BDKRB2 (1.00) BDKRB2
SCHEMBL7749611 0.93 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL7750216 0.92 BDKRB2 (0.99) BDKRB2
SCHEMBL7742686 0.92 BDKRB2 (1.00) BDKRB2
SCHEMBL7742680 0.92 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL7750208 0.92 BDKRB2 (0.99) BDKRB2
SCHEMBL7836428 0.92 BDKRB2 (0.89) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed
EP-0622361-A1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP disclosed